Publications of the group of Prof. Dr. Walter Volknandt

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Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the presynaptic active zone in mouse brain.

Laßek, M; Weingarten, J; Acker-Palmer, A; Bajjalieh, SM; Müller, U; Volknandt, W

Current Alzheimer Research

[accepted for publication]

2014 November


The proteome of the presynaptic active zone from mouse brain.

Weingarten, J; Laßek, M; Mueller, BF; Rohmer, M; Lunger, I; Baeumlisberger, D; Dudek, S; Gogesch, P; Karas, M; Volknandt, W

Molecular and Cellular Neuroscience

59, 106-118

2014 March


Amyloid precursor proteins are constituents of the presynaptic active zone.

Laßek, M; Weingarten, J; Einsfelder, U; Brendel, P; Müller, U; Volknandt, W

Journal of Neurochemistry

127(1), 48-56

2013 October


SV31 is a Zn2+-binding synaptic vesicle protein.

Barth, J; Zimmermann, H; Volknandt, W

Journal of Neurochemistry

118, 558-70

2011 August


Electrophysiological characterization of ATPases in native synaptic vesicles and synaptic plasma membranes.

Obrdlik, P; Diekert, K; Watzke, N; Keipert, C; Pehl, U; Brosch, C; Boehm, N; Bick, I; Ruitenberg, M; Volknandt, W; Kelety, B

Biochem. Journal

427, pp. 151-159

2010 January


The proteome of the presynaptic active zone: from docked vesicles to adhesion molecules and maxi-channels.

Morciano, M; Beckhaus, T; Karas, M; Zimmermann; H, Volknandt

Journal of Neurochemistry

108(3), pp. 662-675

2009 February


Barth, J; Volknandt, W

Evaluation of small hairpin RNA silencing efficiency in live cells by cotransfection of two fluorescent probes.

Analytical Biochemistry

379(1), pp. 133-135


2008 August

Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.

Burré, J; Zimmermann, H; Volknandt, W

Journal of Neurochemistry

103(1), pp. 276-287

2007 October


Immunoisolation and subfractionation of synaptic vesicle proteins.

Burré, J; Zimmermann, H; Volknandt, W

Analytical Biochemistry

362(1), pp. 172-181

2007 October


Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques.

Burré, J; Beckhaus, T; Schägger, H; Corvey, C; Hofmann, S; Karas, M; Zimmermann, H; Volknandt, W


6(23), pp. 6250-62

2006 December 23


Synaptic vesicle proteins under conditions of rest and activation: Analysis by 2-D difference gel electrophoresis.

Burré, J; Beckhaus, T; Corvey, C; Karas, M; Zimmermann, H; Volknandt, W


27(17), pp. 3488-3496

2006 September


Movement of vault particles visualized by GFP-tagged major vault protein.

Slesina, M; Inman, ME; Moore, AE; Goldhaber, JI; Rome; Volknandt, W

Cell and Tissue Research

324(3), pp. 403-410

2006 June


Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.

Morciano, M; Burré, J; Corvey, C; Karas, M; Zimmermann, H; Volknandt, W

Journal of Neurochemistry

95(6), pp. 1732–1745

2005 December


Nuclear localization of the major vault protein in U373 cells.

Slesina, M; Inman, ME; Rome; Volknandt, W

Cell and Tissue Research

321(1), pp. 97-104

2005 Juli


Secretion and molecular forms of NESP55, a novel genomically imprinted neuroendocrine-specific protein from AtT-20 cells.

Eder, S; Leierer, J; Klimaschewski, L; Volknandt, W; Laslop, A; Fischer-Colbrie, R


13(6), pp. 298-307

2004 November


Endosomal ricin transport: involvement of Rab4- and Rab5-positive compartments.

Moisenovich, M; Tonevitsky, A; Maljuchenko, N; Kozlovskaya, N; Agapov, I; Volknandt, W; Bereiter-Hahn, J

Histochemistry and Cell Biology

121(6), pp. 429-439

2004 June


Localization of SNARE proteins and secretory organelle proteins in astrocytes in vitro and in situ.

Wilhelm, A; Volknandt, W; Langer, D; Nolte, C; Kettenmann, H; Zimmermann, H

Neuroscience Research

48(3), pp. 249-257

2004 March


Dufour gland of the digger wasp Liris niger: structure and developmental and biochemical aspects.

Gnatzy, W; Volknandt, W; Schulz, S

Cell and Tissue Research

315(1), pp. 125-138

2004 January


The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles.

Ribeiro, FM; Alves-Silva, J; Volknandt, W; Martins-Silva, C; Mahmud, H; Wilhelm, A; Gomez, MV; Rylett, RJ; Ferguson, SS; Prado VF; Prado, MA

Journal of Neurochemistry

87(1), pp. 136-146

2003 October


Expression and allocation of proteins of the exo-endocytotic machinery in U373 glioma cells.

Volknandt, W; Küster, F; Wilhelm, A; Obermüller, E; Steinmann, A; Zhang, L; Zimmermann, H

Cellular and Molecular Neurobiology

22(2), pp. 153-169

2002 April


Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells.

Ehrnsperger, C;; Volknandt, W

Biolgical Chemistry

382(10), pp. 1463–1471



Venom gland of the digger wasp Liris niger: morphology, ultrastructure, age-related changes and biochemical aspects.

Gnatzy, W; Volknandt, W

Cell and Tissue Research

302(2), pp. 271-284

2000 November


Age-dependent pre- and postsynaptic distribution of AMPA receptors at synapses in CA3 stratum radiatum of hippocampal slice cultures compared with intact brain.

Fabian-Fine, R; Volknandt, W; Fine, A; Stewart, MG

European Journal of Neuroscience

12(10), pp. 3687–3700

2000 October


Membrane Association of Presynaptic Cytomatrix Protein Bassoon.

Sanmarti-Vila, L; tom Dieck, S; Richter, K; Altrock, W; Zhang, L; Volknandt, W; Zimmermann, H; Garner, CC; Gundelfinger, ED; Dresbach

Biochemical and Biophysical Research Communications

275(1), pp. 43–46

2000 August


A comparison of synaptic protein localization in hippocampal mossy fiber terminals and neurosecretory endings of the neurohypophysis using the cryo-immunogold technique.

Zhang, L; Volknandt, W; Gundelfinger, ED; Zimmermann, H

European Journal of Neurocytology

29(1), pp. 19-30

2000 January


Endocytic vacuoles formed following a short pulse of K+-stimulation contain a plethora of presynaptic proteins.

Marxen, M; Volknandt, W; Zimmermann, H


94(3), pp. 985-996

1999 October


Axonal transport of ribonucleoprotein particles (vaults).

Li, JY; Volknandt, W; Herrmann, C; Herrmann, J; Das, B; Zimmermann, H


91(3), pp. 1055-1065

1999 July


A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes.

Maienschein, V; Marxen, M; Volknandt, W; Zimmermann, H


26(3), pp. 233-44.

1999 May


Recombinant Major Vault Protein Is Targeted to Neuritic Tips of PC12 Cells.

Herrmann, C; Golkaramnay, E; Inman, E; Rome, LH; Volknandt, W

The Journal of Cell Biology

144(6), pp. 1163-1172

1999 March


Axonal transport of ribonucleoprotein particles (Vaults).

Li, JY; Volknandt, W; Dahlström, A; Herrmann, C; Blasi, J; Das, B; Zimmermann, H


91(3), pp. 1055–1065

1999 July


Peripheral synapses at identifiable mechanosensory neurons in the spider Cupiennius salei: synapsin-like immunoreactivity.

Fabian-Fine, R; Volknandt, W; Seyfarth, EA

Cell and Tissue Research

295(1), pp. 13-29

1999 January


Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains.

Leitner, B; Schneitler, C; Klocker, H; Volknandt, W; Zimmermann, H; Winkler, H; Fischer-Colbrie, R

Neuroscience Letters

248(2), pp. 105-108

1998 May


Major vault protein of electric ray is a phosphoprotein.

Herrmann, C; Kellner, R; Volknandt, W

Neurochemical Research

23(1), pp. 39-46

1998 January


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Original articles before 1998

Marxen M, Maienschein V, Volknandt W, Zimmermann H (1997) Immunocytochemical localization of synaptic proteins at vesicular organelles in PC12 cells. Neurochem Res 22: 941-950

Herrmann C, Zimmermann H, Volknandt W (1997) Analysis of a cDNA encoding the major vault protein from the electric ray Discopyge ommata. Gene 188: 85-90

Herrmann C, Volknandt W, Wittich B, Kellner R, Zimmermann H (1996) The major vault protein (MVP100) is contained in cholinergic nerve terminals of electric ray electric organ. J Biol Chem 271: 13908-13915

Kretzschmar S, Volknandt W, Zimmermann H (1996) Colocalization on the same synaptic vesicles of syntaxin and SNAP-25 with synaptic vesicle proteins: a re-evaluation of functional models required? Neurosci Res 26: 141-148

Hausinger A, Volknandt W, Kretzschmar S, Kellner R, Zimmermann H (1996) Two synpatic vesicle proteins of 25 kDa: a comparison of the molecular properties and tissue distribution of svp25 and o-rab3. Neurochem Int 28: 251-258

Hausinger A, Volknandt W, Zimmermann H (1995) Calcium-dependent endogenous proteolysis of the vesicle proteins synaptobrevin and synaptotagmin. Neuroreport 6: 637-641

Hausinger A, Volknandt W, Zimmermann H, Habermann E (1995) Inhibition by clostridial neurotoxins of calcium-independent [3H]noradrenaline outflow from freeze-thawed synaptosomes: comparison with synaptobrevin hydrolysis. Toxicon 33: 1519-1530

Wittich B, Volknandt W, Zimmermann H (1994) SV2 and o-rab3 remain associated with recycling synaptic vesicles. J Neurochem 63: 927-937

Schläfer M, Volknandt W, Zimmermann H (1994) Putative synaptic vesicle nucleotide transporter identified as glyceraldehyde-3-phosphate dehydrogenase. J Neurochem 63: 1924-1931

Pevsner J, Volknandt W, Wong BR, Scheller RH (1994) Two rat homologs of clathrin-associated adaptor proteins. Gene 146: 279-283

Volknandt W, Pevsner J, Elferink LA, Scheller RH (1993) Association of three small GTP-binding proteins with cholinergic synaptic vesicles. FEBS Lett 317: 53-56

Zimmermann H, Volknandt W, Wittich B, Hausinger A (1993) Synaptic vesicle life cycle and synaptic turnover. J Physiol Paris 87: 159-170

Volknandt W, Hausinger A, Wittich B, Zimmermann H (1993) The synaptic vesicle-associated G protein o-rab3 is expressed in subpopulations of neurons. J Neurochem 60: 851-857

Volknandt W, Pevsner J, Elferink LA, Schilling J, Scheller RH (1991) A synaptic vesicle specific GTP-binding protein from ray electric organ. Brain Res Mol Brain Res 11: 283-290

Volknandt W, Vogel M, Pevsner J, Misumi Y, Ikehara Y, Zimmermann H (1991) 5'-nucleotidase from the electric ray electric lobe. Primary structure and relation to mammalian and procaryotic enzymes. Eur J Biochem 202: 855-861

Volknandt W, Schläfer M, Bonzelius F, Zimmermann H (1990) Svp25, a synaptic vesicle membrane glycoprotein from Torpedo electric organ that binds calcium and forms a homo-oligomeric complex. Embo J 9: 2465-2470

Volknandt W, Zimmermann H (1990) Identical properties of transmembrane synaptic vesicle protein M(r) 100,000 in Torpedo and M(r) 86,000 in bovine brain. Neurochem Int 16: 539-547

Janetzko A, Zimmermann H, Volknandt W (1989) Intraneuronal distribution of a synaptic vesicle membrane protein: antibody binding sites at axonal membrane compartments and trans-Golgi network and accumulation at nodes of Ranvier. Neuroscience 32: 65-77

Zimmermann H, Volknandt W, Henkel A, Bonzelius F, Janetzko A, Kanaseki T (1989) The synaptic vesicle membrane: origin, axonal distribution, protein components, exocytosis and recycling. Cell Biol Int Rep 13: 993-1006

Kuhn DM, Volknandt W, Stadler H, Zimmermann H (1988) Cholinergic vesicle specific proteoglycan: stability in isolated vesicles and in synaptosomes during induced transmitter release. J Neurochem 50: 11-16

Volknandt W, Henkel A, Zimmermann H (1988) Heterogeneous distribution of synaptophysin and protein 65 in synaptic vesicles isolated from rat cerebral cortex. Neurochem Int 12: 337-345

Volknandt W, Naito S, Ueda T, Zimmermann H (1987) Synapsin I is associated with cholinergic nerve terminals in the electric organs of Torpedo, Electrophorus, and Malapterurus and copurifies with Torpedo synaptic vesicles. J Neurochem 49: 342-347

Volknandt W, Schober M, Fischer-Colbrie R, Zimmermann H, Winkler H (1987) Cholinergic nerve terminals in the rat diaphragm are chromogranin A immunoreactive. Neurosci Lett 81: 241-244

Janetzko A, Zimmermann H, Volknandt W (1987) The electromotor system of the electric catfish (Malapterurus electricus): a fine-structural analysis. Cell Tissue Res 247: 613-624

Volknandt W, Zimmermann H (1986) Acetylcholine, ATP, and proteoglycan are common to synaptic vesicles isolated from the electric organs of electric eel and electric catfish as well as from rat diaphragm. J Neurochem 47: 1449-1462

Volknandt W, Hardeland R (1984) Circadian rhythmicity of protein synthesis in the dinoflagellate, Gonyaulax polyedra: a biochemical and radioautographic investigation. Comp Biochem Physiol 77B: 493-500

Volknandt W, Hardeland R (1984) Effects of aldehydes and alcohols on protein synthesis in the dinoflagellate, Gonyaulax polyedra: relation to phase-shifting potency in the circadian oscillation. Comp Biochem Physiol C 78: 51-54

Volknandt W, Hardeland R (1980) Diurnal rhythm in rat liver 5-aminolevulinate synthetase activity. J. Interdiscipl Cycle Res 11: 1-23

Frank A, Hardeland R, Kolb U, Volknandt W, Kretzer G, Havemann U, Frank H (1978) Effects of adrenergic agonists and antagonists in different phases of the diurnal rhythm of rat liver tyrosine aminotransferase. J Interdiscipl Cycle Res 9: 269-282

Volknandt W, Hardeland R (1978) Circadian rhythmicity of tyrosine aminotransferase in larval and prepupal fat body of Drosophila melanogaster. J Interdiscipl Cycle Res 9: 283-291

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Reviews and book chapters

Laßek M, Weingarten J, Volknandt W (2014) The synaptic proteome. Cell and Tissue Res.

Laßek M, Weingarten J, Volknandt W (2014) The proteome of the murine presynaptic active zone. Proteomes 2, 243-57.

Volknandt W, Karas M (2012) Proteomic analysis of the presynaptic active zone. Exp Brain Res 217:449-461

Barth J, Volknandt W (2011) Proteomic investigations of the synaptic vesicle interactome. Expert review of proteomics 8: 211-220

Barth J, Volknandt W (2011) 2-dimensional BAC-SDS polyacrylamide gel electrophoresis for the fractionation and identification of synaptic vesicle proteins. In Neuroprotomics: Neuromethods, Ka Wan Li (ed), pp 115-125. Springer Protocols, Humana Press.

Burre J, Volknandt W (2007) The synaptic vesicle proteome. J Neurochem 101: 1448-1462

Volknandt W (2002) Vesicular release mechanisms in astrocytic signalling. Neurochem Int 41: 301-306

Volknandt W, Herrmann C (1997) The major protein of a large ribonucleoprotein particle (Vault) is localized in nerve terminals. In: Neurochemistry: Cellular, Molecular and Clinical Aspects (Telken AW, Korf J, eds). Plenum, London, pp675-681

Zimmermann H, Volknandt W, Hausinger A, Herrmann C (1996) Molecular properties and cellular distribution of cholinergic synaptic proteins. Prog Brain Res 109: 31-40

Volknandt W (1995) The synaptic vesicle and its targets. Neuroscience 64: 277-300

Hardeland R, Harnau G, Volknandt W, Rode I, Balzer I (1989) On the transitions between rhythmic and arrhythmic states of the Gonyaulax circadian oscillator. In: Proceedings of the 11th ISB Congress (Driscolol D, Box EO, eds). Academic publishing, The Hague The Netherlands, pp281-285

Volknandt W, Henkel A, Zimmermann H (1988) Synaptic vesicle proteins. In: Cellular and Molecular Basis of Synaptic Transmission (Zimmermann H, ed.), Springer, Berlin, Heidelberg, New York, pp. 337-350

Zimmermann H ., Volknandt W, Grondal EJM (1987) Molecular and functional characterization of cholinergic synaptic vesicles from electric organs of electric fish to rat diaphragm. In: Synaptic Transmitters and Receptors (Tucek S, ed.), Academia, Praha, pp. 47-50, 1987.

Volknandt W, Zimmermann H (1987) Cholinergic synaptic vesicles from electric fishes to rat: Isolation and molecular properties. In: Cellular and Molecular Basis for Cholinergic Function (Dowdall MJ, Hawthorne JN, eds.), Ellis Horwood Ltd., Chichester, England, and VCH, Weinheim, pp. 277-287

Volknandt W, Zimmermann H (1987) Cholinergic synaptic vesicles isolated from motor nerve terminals from electric fishes to rat. Molecular composition and functional properties. In: Cellular and Molecular Biology of Hormone- and Neurotransmitter-Containing Secretory Vesicles (Johnson RG, ed.). Ann NY Acad Sci 493: 159-161

Volknandt W, Zimmermann H (1985) Is ATP a general molecular constituent of cholinergic synaptic vesicles? In: Molecular Basis of Nerve Activity (Changeux J., Hucho F, Maelicke A, Neumann E, eds.), Walter de Gruyter, Berlin, New York, pp. 121-130